View abstract. West J Med 1997;167(3):184-185. We encourage you to discuss any decisions about treatment or care with your health care provider. Z. View abstract. Licorice might also decrease potassium in the body. J Clin Endocrinol Metab 2003;88:2384-92. Braz J Infect Dis 2016;20(6):534-8. Pontefract cakes can be bad for you: refractory hypertension and liquorice excess. View abstract. View abstract. View abstract. View abstract. http://www.meschinohealth.com/books/licorice Yamada, K., Kanba, S., Yagi, G., and Asai, M. Effectiveness of herbal medicine (shakuyaku-kanzo-to) for neuroleptic-induced hyperprolactinemia. Medicinal herbs: modulation of estrogen action. Avoid whole or licorice root if you have high blood pressure, kidney or liver disease, diabetes or heart disease, are pregnant or are breastfeeding. Gardner Z, McGuffin M. Boca Raton, FL: CRC Press, 2013. van Rossum, T. G., Vulto, A. G., Hop, W. C., and Schalm, S. W. Glycyrrhizin-induced reduction of ALT in European patients with chronic hepatitis C. Am J Gastroenterol 2001;96(8):2432-2437. 2011;25(1-2):21-38. Chemicals in licorice may reduce inflammation, thin mucus secretions, decrease cough, and increase the body's ability to heal ulcers. A small number of studies suggest that using a licorice gargle or lozenges before surgery might help to prevent or lessen the severity of the sore throat that often occurs after surgery. American Herbal Products Association's Botanical Safety Handbook, Second Edition. 2000;20(1):38-41. Treatment of duodenal ulcer with glycyrrhizinic-acid-reduced liquorice. Rosenblat, M. and Aviram, M. Paraoxonases role in the prevention of cardiovascular diseases. A dual investigation of the effect of dietary supplementation with licorice flavonoid oil on anthropometric and biochemical markers or health and adiposity. Barrella, M., Lauria, G., Quatrale, R., and Paolino, E. Hypokaliemic rhabdomyolysis associated with liquorice ingestion: report of an atypical case. Using mouthwash containing glycyrrhizin also does not seem to reduce plaque. J Hepatol 1994;21:601-9. View abstract. Gut 1969;10:299-302. Some early research shows that applying a patch containing licorice to the inside of the mouth for 16 hours daily for 8 days reduces the size of canker sores but does not speed up healing time. Taking licorice along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Teelucksingh S, Mackie AD, Burt D, McIntyre MA, Brett L, Edwards CR. Cinatl J, Morgenstern B, Bauer G, et al. Stormer FC, Reistad R, Alexander J. Glycyrrhizic acid in liquorice - evaluation of health hazard. Sucking on a licorice lozenge or gargling with a licorice fluid shortly before placement of a breathing tube seems to help prevent cough and sore throat from occurring when the tube is removed. View abstract. Hinoshita F, Ogura Y, Suzuki Y, et al. Kondo K1, Shiba M, Nakamura R, Morota T, Shoyama Y. View abstract. Phytomedicine 2003;10:271-85. Mouth sores (lichen planus). Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11. Licorice might decrease how quickly the liver breaks down some medications. Health Care Women Int. J Gastroenterol Hepatol 1999;14(11):1093-1099. Schweiz Med Wochenschr 2-26-1977;107(8):276-279. Chen, W. G. and Ba, Z. M. Prof. ZHANG Yi's experience in treating severe arrhythmia. Lipids Health Dis 2011;10:29. Räikkönen K, Seckl JR, Heinonen K, Pyhälä R, Feldt K, Jones A, Pesonen AK, Phillips DI, Lahti J, Järvenpää AL, Eriksson JG, Matthews KA, Strandberg TE, Kajantie E. Maternal prenatal licorice consumption alters hypothalamic-pituitary-adrenocortical axis function in children. View abstract. Janse A, van Iersel M, Hoefnagels WH, Olde Rikker MG. There’s some evidence that topical gels containing licorice root might be helpful for atopic dermatitis symptoms. View abstract. The following doses have been studied in scientific research: View abstract. Tu, J. H., He, Y. J., Chen, Y., Fan, L., Zhang, W., Tan, Z. R., Huang, Y. F., Guo, D., Hu, D. L., Wang, D., and Hong-Hao Zhou. View abstract. View abstract. View abstract. Medicine (Baltimore) 2018;97(11):e0073. Case 30-2020: A 54-Year-Old Man with Sudden Cardiac Arrest. Dai DW, Singh I, Hershman JM. View abstract. View abstract. A randomized, double-blind comparison of licorice versus sugar-water gargle for prevention of postoperative sore throat and postextubation coughing. Title 21. Ito A, Hayashi N, Katayama K, and et al. Br J Clin Pharmacol 2008;66:572-4. View abstract. View abstract. View abstract. typica. J Clin Ther Med 1999;15:499-523. Ital J Neurol Sci 1983;4(4):493-497. Early research suggests that taking licorice root extract daily for 1 month reduces total cholesterol, low-density lipoprotein (LDL or "bad") cholesterol, and triglyceride levels in people with high cholesterol. J Assoc Physicians India 1978;26(9):811-814. (16 oz. Taking a specific licorice product containing certain antacids for 4-16 weeks might speed up ulcer healing. Licorice root may offer potential health benefits, such as fighting infection, preventing tooth decay, and relieving stomach discomfort. View abstract. It’s mostly grown in Greece, Turkey, and western Asia. Website: https://pubmed.ncbi.nlm.nih.gov/. While licorice is commonly … B. Using different formulations together increases the risk of an overdose. View abstract. Immunology 1997;90(1):115-120. Licorice offers numerous unique purposes for … CJEM 2009;11(1):94-96. Hum.Exp Toxicol. Taking licorice along with medications that are broken down by the liver might increase or decrease the effects of these medications. Most licorice is grown in Greece, Turkey, and Asia. In: Coates PM, Betz JM, Blackman MR, et al., eds. van den Bosch AE, van der Klooster JM, Zuidgeest DM, et al. New plants will grow from any bits of root left in the soil, which may make it difficult to clear an area of licorice. QJM 2011;104(12):1093-1095. Clin Neurol Neurosurg 1993;95(1):35-37. 1979;14(5):605-607. Hepatitis. Do not use different forms (powder, root, extract, liquid, teas, etc) of licorice at the same time without medical advice. Luo, Y. G., Liu, Y. Q., and Hu, J. Quiz: What Do You Know About Vitamin B12 Deficiency? Kraus SD, Kaminskis A. Z Kardiol 1991;80(6):389-391. J Nat Prod 1980;43(2):259-269. Pfeifer BL, Pirani JF, Hamann SR, Klippel KF. View abstract. tty (for deaf and hard-of-hearing callers): Email: info@nccih.nih.gov (link sends e-mail). While licorice root may be a common ingredient in many tea blends, finding a pure licorice root tea is a much more difficult task. J Endocrinol Invest 2003;26:646-50. Licorice root has the ability to acquire nitrogen because of it symbiotic relationship with bacteria known as rhizobium, which helps the plant grow efficiently and is a great source for other plants to use nearby. View abstract. View abstract. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Clin Exp Obstet Gynecol 2013;40(1):141-143. Phytother.Res. I. Elucidation of five new flavonoid constituents from the roots of Glycyrrhiza glabra L. collected in Xinjiang. View abstract. View abstract. Licorice Root is a multi-functional botanical, whose chief components include the glycosides glycyrrhizin and glycyrrizinic acid, triterpene saponins and flavonoids. Bisogni V, Rossi GP, Calò LA. J Clin Psychopharmacol 2008;28(3):264-370. Some studies of licorice root in people have been completed, but there isn’t enough high-quality evidence to clearly support its use for any health condition. Bocker, D. and Breithardt, G. [Induction of arrhythmia by licorice abuse]. The root, seed, leaf, and fruit are used to make medicine. Rees, W. D., Rhodes, J., Wright, J. E., Stamford, L. F., and Bennett, A. Taking licorice along with medications that are broken down by the liver might increase or decrease the effects of some medications. Whole licorice root can be used to flavor liquids in the process of making tea or homemade candies. 2008;9(3):88-98. A pilot study. Int J Cardiol 2008;124(3):e42-e44. View abstract. Badr, A. E., Omar, N., and Badria, F. A. View abstract. Intern Med 2017;56(2):175-9. 2009;14(1):64-65. Gibertoni, M., Bonito, V., Colombo, A., Falasca, A., and Nichelli, P. [Licorice-induced myopathy. Acide Glycyrrhizique, Acide Glycyrrhizinique, Alcacuz, Alcazuz, Bois Doux, Bois Sucré, Can Cao, Chinese Licorice, Deglycyrrhized Licorice, East European Licorice, Gan Cao, Gan Zao, Glabra, Glycyrrhiza, Glycyrrhiza echinate, Glycyrrhiza glabra, Glycyrrhiza glabra typica, Glycyrrhiza glabra violacea, Glycyrrhiza glabra glandulifera, Glycyrrhiza glandulifera, Glycyrrhiza Radix, Glycyrrhiza uralensis, Glycyrrhizae, Glycyrrhizic Acid, Glycyrrhizinic Acid, Isoflavone, Jethi-Madh, Kanzo, Lakritze, Licorice Root, Liquiritiae Radix, Liquirizia, Mulathi, Mulethi, Orozuz, Phytoestrogen, Phyto-œstrogène, Racine de Réglisse, Racine Douce, Radix Glycyrrhizae, Régalissse, Regaliz, Reglisse, Réglisse, Réglisse Déglycyrrhisée, Réglisse Espagnole, Réglisse Russe, Regliz, Russian Licorice, Spanish Licorice, Subholz, Sussholz, Sweet Root, Turkish Licorice, Ural Licorice, Yashtimadhu, Yashti-Madhu, Yashti-Madhuka, Zhi Gan Cao. Kent UM, Aviram M, Rosenblat M, Hollenberg PF. View abstract. Aging Clin Exp Res. View abstract. Pseudohyperaldosteronism, liquorice, and hypertension. Effect of glycyrrhizin on viral replication and quasispecies in patients with type C chronic hepatitis. Ethacrynic Acid (Edecrin) interacts with LICORICE. The treatment of human cancer with agents prepared from bovine cartilage. 97 ($1.44/Ounce) An Bras Dermatol 2010;85(5):613-620. View abstract. Menati L, Khaleghinezhad K, Tadayon M, Siahpoosh A. View abstract. Natural Medicines website. J Clin Hypertens (Greenwich) 2008;10:153-7. Crit Care 2011;15(1):R64. Lancet 2-10-1979;1(8111):319. [Effectiveness of interferon, glycyrrhizin combination therapy in patients with chronic hepatitis C]. The NCCIH Clearinghouse provides information on NCCIH and complementary and integrative health approaches, including publications and searches of Federal databases of scientific and medical literature. View abstract. View abstract. View abstract. View abstract. Nutrition 2002;18(3):268-273. View abstract. View abstract. Med Princ Pract 2010;19(6):485-489. Taking licorice and ethacrynic acid (Edecrin) together might cause potassium to become too low. Early research shows that giving licorice oil to older women that exercise does not improve their walking speed or other physical abilities. Dobbins, K. R. and Saul, R. F. Transient visual loss after licorice ingestion. Armanini D, Fiore C, Bielenberg J, et al. View abstract. Sato H, Goto W, Yamamura J, et al. Yoshino T, Yanagawa T, Watanabe K. Risk factors for pseudoaldosteronism with rhabdomyolysis caused by consumption of drugs containing licorice and differences between incidence of these conditions in Japan and other countries: case report and literature review. Schleimer, R. P. Potential regulation of inflammation in the lung by local metabolism of hydrocortisone. View abstract. Acharya SK, Dasarathy S, Tandon A, et al. View abstract. View abstract. Zhongguo Zhong.Xi.Yi Jie.He.Za Zhi 2008;28(12):1121-1123. N Engl J Med 1991;325:1223-7. Sheehan M, Rustin MHA, Atherton DJ, et al. van Uum SH. Sheehan MP, Atherton DJ. Ethacrynic acid (Edecrin) can also cause the body to get rid of potassium. Hussain RM. J Clin Periodontol 1991;18(3):210-212. Gut 1973;14(9):711-715. Nephrologie 1993;14(4):177-181. Some products that contain licorice root and other ingredients may help relieve digestive symptoms. The body breaks down warfarin (Coumadin) to get rid of it. Chem Pharm Bull (Tokyo) 1994;42(5):1056-1062. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Asian Medical Journal 1984;26(7):423-438. Armanini, D., Mattarello, M. J., Fiore, C., Bonanni, G., Scaroni, C., Sartorato, P., and Palermo, M. Licorice reduces serum testosterone in healthy women. This survey is being conducted by the WebMD marketing sciences department. Kinoshita, H., Okabayashi, M., Kaneko, M., Yasuda, M., Abe, K., Machida, A., Ohkubo, T., Kamata, T., and Yakushiji, F. Shakuyaku-kanzo-to induces pseudoaldosteronism characterized by hypokalemia, rhabdomyolysis, metabolic alkalosis with respiratory compensation, and increased urinary cortisol levels. [Clinical characteristics of five elderly patients with severe hypokalemia induced by glycyrrhizin derivatives]. To the companies' credit, she added, "Red Vines and Twizzlers do make black licorices that contain licorice extract," though the items are more popular in Europe. 1991;78(1-2):1-6. Digoxin (Lanoxin) interacts with LICORICE. View abstract. View abstract. Licorice Root This shrubby perennial that bears bluish-purple flowers in summer is a member of the legume family. View abstract. Neth J Med 2005;63:119-20. J Clin Hypertens (Greenwich) 2016;18(2):159-60. View abstract. Effect of Shakuyaku-kanzo-to (Tsumura TJ-68) on muscle cramps accompanying cirrhosis in a placebo-controlled double-blind parallel study. and its bioactive compounds. Antiviral Res 12-11-1988;10(6):289-298. View abstract. A., Braun, T. M., and Jacobson, J. J. [Database subscription]. J Clin Psychopharmacol 2016;36(6):572-9. Electronic Code of Federal Regulations. It is used as a flavoring in candy, other foods, beverages, and tobacco products. Preterm birth and licorice consumption during pregnancy. Some medications are changed and broken down by the liver. 2 in the perioperative stage of laparoscopic cholecystectomy]. 2010 Nov;35(10):1587-93. Antiviral Res 1987;7(3):127-137. View abstract. Canker sores. The COVID-19 outbreak is a rapidly evolving situation. Aoki, F., Nakagawa, K., Kitano, M., Ikematsu, H., Nakamura, K., Yokota, S., Tominaga, Y., Arai, N., and Mae, T. Clinical safety of licorice flavonoid oil (LFO) and pharmacokinetics of glabridin in healthy humans. Lin SH, Yang SS, Chau T, Halperin ML. van Beers, E. J., Stam, J., and van den Bergh, W. M. Licorice consumption as a cause of posterior reversible encephalopathy syndrome: a case report. High levels of a hormone called prolactin in the blood (hyperprolactinemia).. Ai, M., Yamaguchi, T., Odaka, T., Mitsuhashi, K., Shishido, T., Yan, J., Seza, A., and Saisho, H. Objective assessment of the antispasmodic effect of shakuyaku-kanzo-to (TJ-68), a Chinese herbal medicine, on the colonic wall by direct spraying during colonoscopy. Information from this source is evidence-based and objective, and without commercial influence. 2014 Jan;35(1):87-99. View abstract. Ir J Med Sci 2016;185(4):945-7. High cholesterol. Early research shows that using a specific IV licorice product seems to reduce death by about 50%. Am J Med Sci 2003;325:153-6. Licorice root is cultivated throughout Europe, Asia, and the Middle East. Da Nagao, Y., Sata, M., Suzuki, H., Tanikawa, K., Itoh, K., and Kameyama, T. Effectiveness of glycyrrhizin for oral lichen planus in patients with chronic HCV infection. Clinical reduction of S. mutans in pre-school children using a novel liquorice root extract lollipop: a pilot study. Complement Ther Clin Pract. View abstract. A laboratory evaluation of the antibacterial and cytotoxic effect of Liquorice when used as root canal medicament. Fermented milk containing Lactobacillus paracasei and Glycyrrhiza glabra has a beneficial effect in patients with Helicobacter pylori infection: a randomized, double-blind, placebo-controlled study. View abstract. Fatal hypokalaemic alkalosis with tetany during liquorice and P.A.S. View abstract. Build up of fat in the liver in people who drink little or no alcohol (nonalcoholic fatty liver disease or NAFLD). The dose of your warfarin (Coumadin) might need to be changed. View abstract. Clin Ter 1990;132(1):55-58. All information will be used in a manner consistent with the WebMD, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts. An unusual cause of hypokalemic paralysis: chronic licorice ingestion. Endocrinol Jpn 1990;37:331-41. Topical forms of this product are for use only on the skin. Hsu, Y. L., Wu, L. Y., Hou, M. F., Tsai, E. M., Lee, J. N., Liang, H. L., Jong, Y. J., Hung, C. H., and Kuo, P. L. Glabridin, an isoflavan from licorice root, inhibits migration, invasion and angiogenesis of MDA-MB-231 human breast adenocarcinoma cells by inhibiting focal adhesion kinase/Rho signaling pathway. View abstract. Lorenzin, F., Degen, C., Milani, A., Siciliano, M., and Rossi, L. [Pseudo-hyperaldosteronism caused by licorice. The mention of any product, service, or therapy is not an endorsement by NCCIH. 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